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The mechanism may be related to the decreased inflow of iron, TF and TFR1, the upregulation of GPX4, xCT, and FTH1, and the downregulation of ACSL4, MDA and LPO levels

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For instance, TLR-2 and TLR-4 activation were reported during HSV-1 infection of astrocytes, with subsequent IFN type-I expression and up-regulation of the pro-inflammatory cytokine IL-6, which was dependent of viral replication (Villalba et al., 2012)